Timing Issues

Although nothing from Opal Kelly ever fails timing constraints, under some situations(by changing my own timing constraints) I have found that OkHost doesn’t work in the design(Frontpanel support not available). If it were failing because of clocks that interface with it(which I create), I could understand that…but how can it fail to even see the okHost at all. Is there some timing constraint I can add to help? There are some unconstrained clocks in the OK design but obviously I’m not 100% sure if or what they should be constrained to.

To be clear, I have used the system extensively and it does work well until the place/route gets very complicated.